P187 Intestinal ultrasound is accurate for detecting intra-abdominal complications in Crohn’s disease: a meta-analysis

Abstract Background The clinical course of Crohn’s disease (CD) is associated with development complications including strictures and penetrating lesions such as fistulas abscesses. Close monitoring optimizing therapy can prevent these complications. Intestinal ultrasound (IUS) a non-invasive cross-sectional imaging method ideal for frequent assessment activity intra-abdominal In this meta-analysis we provide an updated the diagnostic accuracy IUS its advanced modalities in detection CD compared to endoscopy, MRI/CT, surgery pathology. Methods We conducted literature search Pubmed/MEDLINE EMBASE databases from 01-01-1970 up 17-10-2022 studies describing adult patients related Quality included was assessed QUADAS-2 tool. A univariate random-effects model used calculate test variables, log odds ratio area under pooled ROC (AUC SROC). All data were calculated 95% confidence intervals (CIs). Chi-squared (χ²) assess study heterogeneity p < 0.05 indicating significant heterogeneity. Funnel plots created publication bias. performed using R-package mada. sensitivity specificity Meta-DiSc. Results identified 1506 which 68 systematic review. Twenty-three 3863 overall moderate high risk total 6 meta-analyses performed, both conventional (B-mode) oral contrast (SICUS) diagnosing CD-related Pooled strictures, inflammatory masses by B-mode 3.56 (2,90-4.21), 3.84 (3.28-4.41) 3.97 (3.30-4.64) AUC 0.926, 0.896 0.960 respectively. diagnosis SICUS 4.51 (3.28-5.73), 4.80 (3.46-6.14) 5.46 (3.61-7.30) 0.955, 0.982 0.985, Significant seen between reporting on IUS. Conclusion These results indicate that accurate tool CD. non-invasive, point-of-care modality recommended first-line if there suspicion